2 research outputs found

    Time-based Location Techniques Using Inexpensive, Unsynchronized Clocks in Wireless Networks

    Get PDF
    The ability to measure location using time of flight in IEEE 802.11 networks is impeded by the standard clock resolution, imprecise synchronization of the 802.11 protocol, and the inaccuracy of available clocks. To achieve real-time location with accuracy goals of a few meters, we derive new consensus synchronization techniques for free-running clocks. Using consensus synchronization, we improve existing time of arrival (TOA) techniques and introduce new time difference of arrival (TDOA) techniques. With this common basis, we show how TOA is theoretically superior to TDOA. Using TOA measurements, we can locate wireless nodes that participate in the location system, and using TDOA measurements, we can locate nodes that do not participate. We demonstrate applications using off-the-shelf 802.11 hardware that can determine location to within 3m using simple, existing optimization methods. The synchronization techniques extend existing ones providing distributed synchronization for free-running clocks to cases where send times cannot be controlled and adjusted precisely, as in 802.11 networks. These location and synchronization techniques may be applied to transmitting wireless nodes using any communication protocol where cooperating nodes can produce send and receive timestamps

    Empagliflozin in Patients with Chronic Kidney Disease

    No full text
    Background The effects of empagliflozin in patients with chronic kidney disease who are at risk for disease progression are not well understood. The EMPA-KIDNEY trial was designed to assess the effects of treatment with empagliflozin in a broad range of such patients. Methods We enrolled patients with chronic kidney disease who had an estimated glomerular filtration rate (eGFR) of at least 20 but less than 45 ml per minute per 1.73 m(2) of body-surface area, or who had an eGFR of at least 45 but less than 90 ml per minute per 1.73 m(2) with a urinary albumin-to-creatinine ratio (with albumin measured in milligrams and creatinine measured in grams) of at least 200. Patients were randomly assigned to receive empagliflozin (10 mg once daily) or matching placebo. The primary outcome was a composite of progression of kidney disease (defined as end-stage kidney disease, a sustained decrease in eGFR to < 10 ml per minute per 1.73 m(2), a sustained decrease in eGFR of & GE;40% from baseline, or death from renal causes) or death from cardiovascular causes. Results A total of 6609 patients underwent randomization. During a median of 2.0 years of follow-up, progression of kidney disease or death from cardiovascular causes occurred in 432 of 3304 patients (13.1%) in the empagliflozin group and in 558 of 3305 patients (16.9%) in the placebo group (hazard ratio, 0.72; 95% confidence interval [CI], 0.64 to 0.82; P < 0.001). Results were consistent among patients with or without diabetes and across subgroups defined according to eGFR ranges. The rate of hospitalization from any cause was lower in the empagliflozin group than in the placebo group (hazard ratio, 0.86; 95% CI, 0.78 to 0.95; P=0.003), but there were no significant between-group differences with respect to the composite outcome of hospitalization for heart failure or death from cardiovascular causes (which occurred in 4.0% in the empagliflozin group and 4.6% in the placebo group) or death from any cause (in 4.5% and 5.1%, respectively). The rates of serious adverse events were similar in the two groups. Conclusions Among a wide range of patients with chronic kidney disease who were at risk for disease progression, empagliflozin therapy led to a lower risk of progression of kidney disease or death from cardiovascular causes than placebo
    corecore